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Center of Excellence in Genomic Science

Genetic differences between individuals influence susceptibility to disease. The Human Genome Project, together with the HapMap project and the Human Cancer Genome Project, have greatly accelerated the ability to find genetic variants and associated disease genes. Despite these advances, linking individual genes and their variations to disease remains daunting. Even where a causal variant has been identified, the biological insights have been slow in coming. The phenotypic effects of functional sequence variants are mediated through dynamic networks of gene products and metabolites. Making sense of genotype-phenotype relationships thus requires that phenotypes be viewed as manifestations of network properties, rather than simply the result of genomic variations considered individually. more …